Dry skin is a common problem that may be caused by various factors such as lifestyle, inappropriate environmental factors, weak barrier function of the skin, and also due to the presence of stimuli such as inappropriate soaps, detergents and some special chemicals, among which, severe dryness can lead to painful cracks and fissures and thus increase the risk of skin infections and diseases, so keeping the skin moisturized can delay the process of skin erosion and protect the skin from sudden changes in weather and other stimuli. has an important role in freshness, freshness and rejuvenation of the skin. Also, since the ultraviolet rays of the sun and the aging factor cause a decrease in the level of vitamin E and cause serious damage to the skin tissue, therefore, topical products containing this compound, which is a non-invasive method of protecting the skin and also one of the It is considered an important and very competitive priority in various cosmetic, health and pharmaceutical industries, it can be useful in reducing skin damage caused by vitamin E deficiency. Also, on the other hand, due to the lack of domestic market production and the import of similar products. Foreign, officially or smuggled, the ability to provide such products to the domestic market and to improve common commercial formulations with the correct technical knowledge is felt with greater need. But since the outer layer of the skin acts as a natural and protective barrier, therefore, local drug delivery through the skin is very challenging. Therefore, many drugs will not be able to penetrate the skin and reach the necessary therapeutic concentration. In the meantime, the use of nanostructured drug carriers (NLCs) in the preparation of pharmaceutical, cosmetic and health products is one of the effective techniques to increase skin permeability and drug delivery. Therefore, in the mentioned company, the formulation of softening and moisturizing cream, with the aim of increasing the absorption and penetration of effective substances in the deep layers of the skin in order to eliminate dryness, moisturizing, softening, repairing, increasing the covering power and thus improving the effectiveness , is designed based on the system of nanostructured lipid carriers (NLCs). This selective carrier system is one of the most efficient and safe drug delivery systems, which is one of the potentially attractive and marketable choices in the field of skin drug delivery, and with some unique features, such as proper stability of the formulation, no use of solvents Allergenic organic, non-toxicity, low irritation, high reproducibility, biocompatibility, the possibility of production in high industrial scales, the ease of its preparation method, it has more efficiency and performance. Also, nanoparticles by providing unique properties , including small size, large contact surface, loading large volume of effective materials and improving their performance, are of interest.

Also, on the other hand, the use of topical skin products in order to solve the problem of dryness and reduce the risk of skin diseases is one of the priorities of various cosmetic, health and pharmaceutical industries, and due to the problem of penetration of some natural active ingredients, such as The instability and low level of their permeability, and on the other hand, the presence of stratum corneum in the outermost layer of the skin, which is a barrier to the passage of effective skin substances, therefore, the need to create a safe substrate, which has the ability to penetrate the active compounds into the deep layer of the skin and release them optimally. Provide these materials well, it will be felt with more need. Therefore, in the formulation of the present product, with the aim of increasing the absorption and permeability of natural active substances in the deep layers of the skin, in order to relieve the dryness of the skin, increase the covering power and thus improve the effectiveness, nanoparticle carriers (NLCs) have been used, which The effective loading of the vitamin E antioxidant composition as well as vegetable oils and natural lipids creates a thin water-repellent coating on the skin surface, which prevents the loss of moisture due to evaporation, and therefore it is expected to have a high performance and acceptability. to have Also, the presence of softening, moisturizing and restorative features of this cream with the ability to quickly absorb into the skin due to the presence of nanostructured lipid carriers in the base of the formulation, and subsequently, the feature of proper spreading, quick removal after washing, and no greasy appearance. On the skin after use, it can be one of the special features of this cream compared to similar non-nano creams. Therefore, it can be safely said that the design of the formulation of the mentioned nano product due to the use of a new method of drug delivery based on nanotechnology is placed in the field of high technologies, and the production process of this product, according to the method of production and the equipment used, also has technical complexity. .